반응 #2066031

반응 방정식

3-[4-chloro-3-formylphenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

1,3-propanediol

p-toluenesulfonic acid

→

3-[4-Chloro-3-(1,3-dioxan-2-yl)-phenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

용매

dichloromethane

반응 조건

후처리

1. 1
   세척The solution was washed with 10% strength sodium bicarbonate solution and water
2. 2
   건조dried over sodium sulfate
3. 3
   기타evaporated down
4. 4
   기타The residue was chromatographed over silica gel (7:3 cyclohexane/ethyl acetate)

실험 절차

A solution of 3.5 g of 3-[4-chloro-3-formylphenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine, 0.8 g of 1,3-propanediol and 0.2 g of p-toluenesulfonic acid in 100 ml of anhydrous dichloromethane was boiled for 5 hours under a water separator. The solution was washed with 10% strength sodium bicarbonate solution and water, dried over sodium sulfate and evaporated down. The residue was chromatographed over silica gel (7:3 cyclohexane/ethyl acetate).

출처