반응 #2066028

반응 방정식

water

3-(4-chloro-3-formylphenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

diethyl cyanomethylphosphonate

potassium carbonate

→

3-[4-Chloro-3-(2-cyanoethenyl)-phenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

용매

dimethylformamide

dimethylformamide

반응 조건

후처리

1. 1
   기타the precipitate which had separated out
2. 2
   기타was isolated
3. 3
   세척washed with water and petroleum ether
4. 4
   기타dried

실험 절차

3.3 g of 3-(4-chloro-3-formylphenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine in 30 ml of dimethylformamide were added dropwise to a suspension of 1.8 g of diethyl cyanomethylphosphonate and 1.5 g of potassium carbonate in 120 ml of dimethylformamide, and stirring was carried out for 20 hours at room temperature. Thereafter, 150 ml of water were added and the precipitate which had separated out was isolated, washed with water and petroleum ether and dried.

출처