반응 #2063062

반응 방정식

4-(3,4-dichlorophenyl)-1-piperazineethanamine

4-methyl-1-isothiocyanatobenzene

→

N-(4-methylphenyl)-N′-[2-[4-(3,4-dichlorophenyl)-1-piperazinyl]ethyl]thiourea

수율 99.2%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타The solvent was evaporated
2. 2
   기타The residue was recrystallized from DIPE
3. 3
   여과The precipitate was filtered off
4. 4
   기타dried
5. 5
   기타The product was used without further purification

실험 절차

A mixture of 4-(3,4-dichlorophenyl)-1-piperazineethanamine (0.01 mol) and 4-methyl-1-isothiocyanatobenzene (0.01 mol) in tetrahydrofuran (300 ml) was stirred at room temperature for 1 hour. The solvent was evaporated. The residue was recrystallized from DIPE. The precipitate was filtered off and dried. The product was used without further purification, yielding 4.2 g N-(4-methylphenyl)-N′-[2-[4-(3,4-dichlorophenyl)-1-piperazinyl]ethyl]thiourea (interm. 6).

출처