반응 #2045068

ord-6590e56c2ed6446192de1773eca39572

반응 방정식

COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1.Cl
Doxorubicin hydrochloride
O=C1c2ccccc2C(=O)c2cc3ccccc3cc21
5,12-Naphthacenedione
→
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1
Doxorubicin

반응물

—
DNA
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1.Cl
Doxorubicin hydrochloride
O=C1c2ccccc2C(=O)c2cc3ccccc3cc21
5,12-Naphthacenedione
—
nucleic acid
—
(8s-ds)-10-[(3-amino-2,3,6trideoxy-a-L-Iyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,1 1-trihydroxy-g-(hydroxyacetyl)1-methoxy-hydrochloride

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Doxorubicin hydrochloride, 5,12-Naphthacenedione, (8s-ds)-10-[(3-amino-2,3,6trideoxy-a-L-Iyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,1 1-trihydroxy-g-(hydroxyacetyl)1-methoxy-hydrochloride (hydroxydaunorubicin hydrochloride, Adriamycin) is used in a wide antineoplastic spectrum. It binds to DNA and inhibits nucleic acid synthesis and mitosis, and promotes chromosomal aberrations.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08409813B2uspto-grants-2013_04