반응 #2045066

반응 방정식

Ethyl 4-(2,2,3-trimethylcyclopent-3-enyl)but-2-enoate

THF

→

4-(2,2,3-trimethylcyclopent-3-enyl)but-2-enoic acid

수율 90.4%

용매

NaOH

NaOH

반응 조건

후처리

1. 1
   기타Upon completion of the reaction
2. 2
   세척the aqueous layer was washed twice with MTBE (10 ml×2)
3. 3
   workup.ADDITIONThe aqueous layer was treated with aqueous 1.0 N HCl until it
4. 4
   추출extracted three times with AcOEt (10 ml×3)
5. 5
   농축The combined AcOEt extracts were concentrated in vacuo
6. 6
   기타purified via flash column chromatography with MTBE/Hexanes (5-20% gradient)

실험 절차

Ethyl 4-(2,2,3-trimethylcyclopent-3-enyl)but-2-enoate (2.0 g, 9.0 mmol) was added to THF (10 ml) in a 50 ml round bottom flask. Aqueous 1 N NaOH (10 ml) was then added to the flask and the reaction mixture was refluxed at 83° C. for 19 h. Upon completion of the reaction, the reaction mixture was diluted with 1 N NaOH (10 ml) and the aqueous layer was washed twice with MTBE (10 ml×2). The aqueous layer was treated with aqueous 1.0 N HCl until it reached a pH of about 3 (for example from 2 to 4), then extracted three times with AcOEt (10 ml×3). The combined AcOEt extracts were concentrated in vacuo and purified via flash column chromatography with MTBE/Hexanes (5-20% gradient) to give 4-(2,2,3-trimethylcyclopent-3-enyl)but-2-enoic acid (1.58 g) as a viscous oil (1.58 g, 90%). The NMR data is indicated below.

출처