반응 #2045056

반응 방정식

2-Methoxycarbonylmethoxybenzoic acid methyl ester

2-Methoxycarbonylmethoxy-benzoic acid methyl ester

NaOH

HCl

→

91

수율 78.2%

2-Carboxymethoxy-benzoic acid

수율 78.2%

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled to room temperature
2. 2
   기타Crude 91 was purified
3. 3
   workup.DISSOLUTIONby dissolving in 10% aqueous NaOH
4. 4
   기타precipitated

실험 절차

2-Methoxycarbonylmethoxybenzoic acid methyl ester 1 (95 g, 424 mmol) was added to a 10% aqueous NaOH solution (475 ml) and heated at 80° C. for 4 hrs. The reaction mixture was cooled to room temperature and pH adjusted to 2 with dilute HCl. Crude 91 was purified by dissolving in 10% aqueous NaOH and precipitated by acidifying with HCl, to get pure 91 (65 g, 78.2%) as a white powder. M.p: 189-192° C.

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