반응 #2045055

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6-[4-(6-Benzyloxyhexanoylamino)phenoxy]hexanoic acid methyl ester

→

81

수율 62.8%

6-[4-(6-Hydroxyhexanoylamino)phenoxy]hexanoic acid methyl ester

수율 62.8%

용매

methanol

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후처리

1. 1
   기타Catalyst was removed by filtration and methanol
2. 2
   workup.DISTILLATIONdistilled off
3. 3
   기타Crude 81 was purified by column chromatography on silica gel

실험 절차

6-[4-(6-Benzyloxyhexanoylamino)phenoxy]hexanoic acid methyl ester 80 (10 g, 22.67 mmol) was dissolved in methanol (100 ml) in a pressure vessel, palladium on carbon (5%, 6 grams) added, and the mixture stirred under a hydrogen atm. (4 Kg) for 20 hrs. Catalyst was removed by filtration and methanol distilled off. Crude 81 was purified by column chromatography on silica gel using chloroform as eluant to give pure 81 (5 g, 62.8%) as a white powder. M.p: 73-75.5°

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