반응 #2045054

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2-[4-(6-Benzyloxyhexanoylamino)phenoxy]propionic acid methyl ester

→

79

수율 51.6%

2-[4-(6-Hydroxyhexanoylamino)phenoxy]propionic acid methyl ester

수율 51.6%

용매

methanol

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후처리

1. 1
   기타Catalyst was removed by filtration and methanol
2. 2
   workup.DISTILLATIONdistilled off
3. 3
   기타The crude 79 was purified by column chromatography on silica gel

실험 절차

2-[4-(6-Benzyloxyhexanoylamino)phenoxy]propionic acid methyl ester 78 (15 g, 37.59 mmol) was dissolved in methanol (150 ml) in a pressure vessel, palladium on carbon (50% wet, 5%, 15 g) added and the mixture stirred under a hydrogen atmosph. (4 Kg) for 16 hrs. Catalyst was removed by filtration and methanol distilled off. The crude 79 was purified by column chromatography on silica gel using chloroform as eluant to get pure 79 (6 g, 51.6%) as a white powder. M.p: 62-64.5° C.

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