반응 #2045047

반응 방정식

4-(2-Benzyloxyacetylamino)-phenoxyacetic acid methyl ester

4-(2-Benzyloxyacetylamino)phenoxyacetic acid methyl ester

→

67

수율 77.0%

4-(2-Hydroxyacetylamino)phenoxyacetic acid methyl ester

수율 77.0%

용매

methanol

반응 조건

후처리

1. 1
   기타Catalyst was removed by filtration and methanol
2. 2
   workup.DISTILLATIONdistilled off
3. 3
   기타Crude 67 was recrystallised in chloroform:hexane (1:6)

실험 절차

4-(2-Benzyloxyacetylamino)-phenoxyacetic acid methyl ester 66 (25 g, 76 mmol) was dissolved in methanol (450 ml) in a pressure vessel, palladium on carbon (5%, 10 g) added and the mixture stirred under a hydrogen atm. (2 Kg) for 5 hrs. Catalyst was removed by filtration and methanol distilled off. Crude 67 was recrystallised in chloroform:hexane (1:6) to give pure 67 (14 g) as a white powder. M.p: 147.5-150° C.

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