반응 #2045045

반응 방정식

2-(4-nitrophenoxy)ethoxyacetic acid methyl ester

[2-(4-Nitrophenoxy)ethoxy]acetic acid methyl ester

→

60

수율 71.1%

2-(4-Aminophenoxy)ethoxyacetic acid methyl ester

수율 71.1%

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타for 30 min
2. 2
   여과Catalyst was filtered
3. 3
   농축filtrate concentrated
4. 4
   workup.ADDITIONhexane (3 ml) added
5. 5
   여과the solid filtered

실험 절차

2-(4-nitrophenoxy)ethoxyacetic acid methyl ester 59 (1 g, 3.9 mmol) was dissolved in anhydrous ethyl acetate (20 ml), palladium carbon (10%, 0.1 g) added and the mixture stirred under a hydrogen atm. using a balloon for 30 min. Catalyst was filtered, filtrate concentrated, hexane (3 ml) added, and the solid filtered to give 60 (625 mg, 70.9%) as a light brown powder. M.p: 51-52.5° C.

출처