반응 #2045039

반응 방정식

6-(4-nitrophenoxy) hexanoic acid methyl ester

6-(4-Nitro-phenoxy)-hexanoic acid methyl ester

→

53

수율 80.2%

6-(4-Nitrophenoxy)-hexanoic acid

수율 80.2%

용매

HCl

반응 조건

후처리

1. 1
   온도was refluxed for 16 hours
2. 2
   여과filtered
3. 3
   기타dried
4. 4
   기타recrystallised from a mixture of ethyl acetate:hexane (1:6)

실험 절차

A mixture of 6-(4-nitrophenoxy) hexanoic acid methyl ester 39 (125 g, 468.16 mmol) and concentrated HCl (1250 ml) was refluxed for 16 hours. The reaction mixture was cooled to room temperature, filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 53 (95 g, 80.2%) as a white powder. M.p: 104-107° C.

출처