반응 #2045035

반응 방정식

2-(4-Nitro-phenoxy)-propionic acid

ethylene glycol

HCl

→

48

수율 56.8%

2-(4-Nitro-phenoxy)-propionic acid 2-hydroxy-ethyl ester

수율 56.8%

용매

water

반응 조건

후처리

1. 1
   기타for 1½ hours
2. 2
   기타During HCl gas bubbling the temp
3. 3
   기타rose to 60° C
4. 4
   기타The crude reaction mass
5. 5
   추출Crude 48 was extracted into chloroform
6. 6
   건조dried over Na2SO4
7. 7
   workup.DISTILLATIONdistilled
8. 8
   기타purified by column chromatography on silica gel

실험 절차

To a mixture of 2-(4-Nitro-phenoxy)-propionic acid 47 (45 g, 213 mol) and ethylene glycol (135 ml) was passed dry HCl gas for 1½ hours. During HCl gas bubbling the temp. rose to 60° C. The crude reaction mass was poured onto cold water (600 ml). Crude 48 was extracted into chloroform, dried over Na2SO4, distilled and purified by column chromatography on silica gel using hexane as eluant to give pure 48 (28 g, 56.8%) as a syrup.

출처