반응 #2045007

반응 방정식

2-(4-Acetylaminophenoxy)propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

17

수율 98.1%

2-(4-Amino-phenoxy)-propionic acid

수율 98.1%

용매

hydrochloric acid

반응 조건

후처리

1. 1
   온도was refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   여과filtered hot
4. 4
   여과filtered
5. 5
   기타dried

실험 절차

A mixture of 2-(4-Acetylaminophenoxy)propionic acid methyl ester 16 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 17 (240 g, 81.7%) as a brown powder. The melting point was found to be 175-180° C.

출처