반응 #2042359

반응 방정식

4-phenoxypiperidine

1-bromo-3-(4-fluorophenoxy)propane

potassium carbonate

→

title compound

4-Phenoxy-1-[(4-fluorophenoxy)propyl]piperidine

용매

acetone

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 12 hours

실험 절차

A mixture of 4-phenoxypyridine and benzylbromide in acetone was stirred overnight at room temperature. After removal of the solvent, the residue was dissolved in methanol, cooled to -20° C. and treated portionwise with sodium borohydride, and warmed to 0° C. After a standard workup and purification, the resulting tetrahydropyridine adduct was dissolved in methanol and hydrogenated using 20% Pd-C as a catalyst to provide 4-phenoxypiperidine. A mixture of 4-phenoxypiperidine and 1-bromo-3-(4-fluorophenoxy)propane in acetone with excess potassium carbonate was heated at reflux for 12 hours to give the title compound.

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