반응 #2041619

ord-75eb580ceef04648af3b25b9f00fde1a

반응 조건

온도
-78°CELSIUS
상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타was spontaneously brought to room temperature
  2. 2
    온도cooled again to -78° C
  3. 3
    기타to rise spontaneously to room temperature
  4. 4
    기타A red homogeneous reaction solution was thereby obtained
  5. 5
    세척This reaction solution was washed with a saturated sodium chloride solution
  6. 6
    기타the solvent was evaporated off
  7. 7
    기타The residue was purified by column chromatography
  8. 8
    기타to obtain 7.6 g of slightly yellowish white solid
  9. 9
    온도The mixture was cooled to -78° C
  10. 10
    기타was brought to room temperature

실험 절차

Into a one-liter Schlenk flask were placed 4.26 g of 2-dimethylaminofluorene and 250 mL of tetrahydrofuran. The flask was cooled to -78° C. Into the flask, 11 mL of a 1.72N n-BuLi solution in hexane was gradually added dropwise. The reaction solution was spontaneously brought to room temperature, and then cooled again to -78° C. Thereto, a solution of 5.1 g of diphenylfulvene in 250 mL of tetrahydrofuran was gradually added dropwise. The mixture was stirred vigorously overnight while the temperature thereof was allowed to rise spontaneously to room temperature. A red homogeneous reaction solution was thereby obtained. This reaction solution was washed with a saturated sodium chloride solution, and the solvent was evaporated off. The residue was purified by column chromatography to obtain 7.6 g of slightly yellowish white solid. This solid was placed in another Schlenk flask together with 250 mL of tetrahydrofuran. The mixture was cooled to -78° C. Thereto, 6.5 mL of a 1.72N n-BuLi solution in hexane was gradually added dropwise, and then the mixture was brought to room temperature. To this reaction solution, a solution of 1.15 g of zirconium tetrachloride in 100 mL of tetrahydrofuran was introduced slowly to obtain 1.15 g of intended diphenylmethylene(cyclopentadienyl)(2-dimethylaminofluorenyl)zirconium dichloride. This compound was identified by 1H-NMR as shown in Table 1.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06121396uspto-grants-2000_09