반응 #2033437

반응 방정식

K2CO3

1-methyl piperazine

5-Fluoro-3-chloro-benzonitrile

HCl

→

3-chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile

수율 93.0%

용매

Diethyl ether

DMSO

반응 조건

후처리

1. 1
   여과A precipitate was filtered off from the crude
2. 2
   기타reaction mixture

실험 절차

5-Fluoro-3-chloro-benzonitrile (1 g, 6.4 mmol) was dissolved in DMSO (20 ml) followed by addition of K2CO3 (1.3 g, 9.6 mmol) and 1-methyl piperazine (1.4 ml, 12.8 mmol). The reaction mixture was heated at 80° C. for 20 hours. Diethyl ether was added to the crude material (10 ml) then acidified with 1N HCl. A precipitate was filtered off from the crude reaction mixture to give 3-chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile (1.4 g, 93% yield) as a white solid (LC/MS: Rt 1.83 [M+H]+ 236, acidic method).

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