반응 #2028896

반응 방정식

HCl

caprolactone

Caprolactone

potassium hydroxide

methanol

→

6-hydroxyhexanoic acid

용매

THF

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   세척The combined organic layers were washed with water
3. 3
   기타dried
4. 4
   여과filtered
5. 5
   농축concentrated

실험 절차

First, the synthesis of Compound 20 was preformed following the procedure reported in PCT/JP2005/004389. 6-Hydroxyhexanoic acid was synthesized by base hydrolysis of caprolactone. Caprolactone (100 g) was added to a mixture of potassium hydroxide (145 g), methanol (110 mL), and THF (390 mL). The resulting mixture was stirred at room temperature overnight. The solution was then acidified with HCl and extracted with ethyl acetate. The combined organic layers were washed with water, dried, filtered, and concentrated to obtain 6-hydroxyhexanoic acid. 1H NMR (CDCl3, 500 MHz) δ 1.44 (m, 2H), 1.60 (m, 2H), 1.68 (m, 2H), 2.37 (t, J=7.5 Hz, 2H), 3.66 (t, J=6.5 Hz, 2H), 5.80 (br, 1H).

출처