반응 #2028891

반응 방정식

4-[4-methyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

N-bromosuccinimide

→

desired product

4-[4-bromomethyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

용매

carbon tetrachloride

benzene

반응 조건

후처리

1. 1
   기타The mixture was irradiated with a sunlamp for 3.5 hours
2. 2
   기타The reaction mixture was partitioned between dichloromethane and water
3. 3
   기타the organic solution was dried
4. 4
   농축concentrated

실험 절차

To a solution of 4-[4-methyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide prepared in Example 201 (500 mg, 1.3 mmol) in carbon tetrachloride (9 mL) and benzene (4 mL) was added N-bromosuccinimide (285 mg, 1.6 mmol). The mixture was irradiated with a sunlamp for 3.5 hours. The reaction mixture was partitioned between dichloromethane and water and the organic solution was dried and concentrated to give the desired product, 412 mg (69%).

출처