반응 #2028884

반응 방정식

HCl

sodium methoxide

Ethyl trifluoroacetate

6-methyltetralone

→

oil

수율 85.1%

6-methyl-2-(trifluoroacetyl)tetralone

수율 85.1%

용매

ether

반응 조건

후처리

1. 1
   기타The organic layer was collected
2. 2
   세척washed with brine
3. 3
   건조dried over MgSO4
4. 4
   농축concentrated in vacuo

실험 절차

Ethyl trifluoroacetate (5.33 g, 37.5 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in methanol, 9.92 g, 45.9 mmol) followed by 6-methyltetralone (5.94 g, 37.1 mmol). The reaction was stirred at room temperature for 6.1 hours then treated with 1N HCl (20 mL). The organic layer was collected, washed with brine, dried over MgSO4, and concentrated in vacuo to give a brown oil (8.09 g) that was used in the next step without further purification.

출처