반응 #2028340

ord-4f89a5a72bc14bb1b5b9aaa37036386f

반응 방정식

C[C@H]1CO[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](O)CC[C@]6(C)[C@H]5[C@H]5O[C@H]5[C@]4(C)[C@H]3[C@@H]2C)C(Br)C1
(3β,5α,11β,12β,25R)-23-bromo-11,12-epoxyspirostan-3-ol
O=C(O)C(Cl)(Cl)Cl
trichloroacetic acid
→
C[C@H]1CO[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](O)CC[C@]6(C)[C@H]5[C@@H](O)[C@H](OC(=O)C(Cl)(Cl)Cl)[C@]4(C)[C@H]3[C@@H]2C)C(Br)C1
title compound
C[C@H]1CO[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](O)CC[C@]6(C)[C@H]5[C@@H](O)[C@H](OC(=O)C(Cl)(Cl)Cl)[C@]4(C)[C@H]3[C@@H]2C)C(Br)C1
(3β,5α,11β,12α,25R)-23-bromo-12-(trichloroacetoxy)spirostan-3,11-diol

반응물

C[C@H]1CO[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](O)CC[C@]6(C)[C@H]5[C@H]5O[C@H]5[C@]4(C)[C@H]3[C@@H]2C)C(Br)C1
(3β,5α,11β,12β,25R)-23-bromo-11,12-epoxyspirostan-3-ol
O=C(O)C(Cl)(Cl)Cl
trichloroacetic acid

시약

없음

용매

Cc1ccccc1
toluene

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Using the procedure described in J. Chem. Soc., 1956, 4330, (3β,5α,11β,12β,25R)-23-bromo-11,12-epoxyspirostan-3-ol was treated with trichloroacetic acid in toluene at room temperature for 3 days to give the title compound.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05703052uspto-grants-1997_12