반응 #2027415

반응 방정식

isobutyraldehyde

1,4-dichloro-2,3-butanediol

sulfuric acid

→

2-Isopropyl-4,5-dichloromethyl-1,3-dioxolane

용매

EDC

반응 조건

후처리

1. 1
   기타A three-neck 5-mL flask fitted with a thermometer, mechanical stirrer, addition funnel, condenser and positive nitrogen atmosphere
2. 2
   기타the flask was immersed in an ice bath
3. 3
   온도to maintain a reaction temperature of 17°-19° C
4. 4
   기타was then continued at ambient temperature
5. 5
   기타(20° C.)
6. 6
   기타for five hours

실험 절차

A three-neck 5-mL flask fitted with a thermometer, mechanical stirrer, addition funnel, condenser and positive nitrogen atmosphere was charged with EDC (200 mL), isobutyraldehyde (11.3 g, 0.157 mole), and 1,4-dichloro-2,3-butanediol (25.0 g, 0.157 mole). Concentrated sulfuric acid (23.2 g) was added dropwise to the agitated mixture over thirty minutes, during which time a slight exotherm was noticed and the flask was immersed in an ice bath to maintain a reaction temperature of 17°-19° C. Stirring was then continued at ambient temperature (20° C.) for five hours.

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