반응 #2027389

반응 방정식

tetrahydrofuran

(3R,5S)-7-Chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid

aluminum lithium hydride

→

non-crystalline solid

수율 88.2%

(3R,5S)-7-Chloro-5-(2-chlorophenyl)-3-(2-hydroxyethyl)-1-neopentyl-1,2,3,5-tetrahydro-4,1-benzoxazepine

수율 88.2%

용매

water

반응 조건

후처리

1. 1
   온도The mixture was heated for 6 hours
2. 2
   온도under reflux, to which
3. 3
   여과Insolubles were then filtered off
4. 4
   농축The filtrate was concentrated
5. 5
   기타which was purified by means of a silica gel column chromatography (hexane

실험 절차

To tetrahydrofuran (20 ml) were added (3R,5S)-7-Chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid (2 g) and aluminum lithium hydride (0.4 g). The mixture was heated for 6 hours under reflux, to which was added water. Insolubles were then filtered off. The filtrate was concentrated, which was purified by means of a silica gel column chromatography (hexane:acetic acid ethyl ester=2:1 v/v as an eluent) to give 1.65 g of non-crystalline solid matter.

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