반응 #2025985

반응 방정식

4-amino-α,α,-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol

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4-Amino-α,α,-dimethyl-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinoline-1-ethanol

용매

trifluoroacetic acid

반응 조건

후처리

1. 1
   기타was hydrogenated at 50 psi (3.44×105Pa) overnight
2. 2
   여과The reaction mixture was filtered
3. 3
   기타to remove the catalyst
4. 4
   농축then concentrated under vacuum
5. 5
   workup.ADDITIONThe residue was diluted with water
6. 6
   기타The resulting precipitate was isolated by filtration

실험 절차

Platinum (IV) oxide (0.3g) was added to a suspension of 4-amino-α,α,-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol (0.5 g, 1.95 mmole, U.S. Pat. No. 4,689,338 Example 189) in trifluoroacetic acid (15 mL). The mixture was hydrogenated at 50 psi (3.44×105Pa) overnight. The reaction mixture was filtered to remove the catalyst then concentrated under vacuum. The residue was diluted with water then combined with aqueous sodium bicarbonate. The resulting precipitate was isolated by filtration. The nuclear magnetic resonance spectroscopy indicated the reduced product.

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