반응 #2025291

반응 방정식

sodium hydride

hexyl p-toluenesulfonate

dimethylformamide

(+)-2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine

→

(+)-2-{4-(1-hexyloxyethyl)phenyl}-5-decyloxypyrimidine

수율 82.1%

용매

water

반응 조건

후처리

1. 1
   기타to subject to reaction at the same temperature for 2 hours
2. 2
   기타After completion of the reaction
3. 3
   추출extracted with 200 ml of toluene
4. 4
   기타followed by separation
5. 5
   세척the organic phase was washed with water sufficiently
6. 6
   건조by drying over anhydrous magnesium sulfate
7. 7
   workup.DISTILLATIONAfter the solvent was distilled off under reduced pressure
8. 8
   기타the resulting residue was purified by silica gel column chromatography (eluent; toluene:ethyl acetate)

실험 절차

Into 20 ml of anhydrous dimethylformamide were dissolved 1.78 g (5 millimole) of the (+)-2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine obtained in Preparation Example [starting material compound (VI)] 70, and then 0.24 g (6 millimole) of 60% sodium hydride was added thereto, followed by stirring at 40° C. for 1 hour. Subsequently, 1.79 g (7 millimole) of hexyl p-toluenesulfonate were added thereto, to subject to reaction at the same temperature for 2 hours. After completion of the reaction, the reaction mixture was poured into 200 ml of water, extracted with 200 ml of toluene, followed by separation thereof, and the organic phase was washed with water sufficiently, followed by drying over anhydrous magnesium sulfate. After the solvent was distilled off under reduced pressure, the resulting residue was purified by silica gel column chromatography (eluent; toluene:ethyl acetate) to obtain 1.81 g (yield: 82%) of (+)-2-{4-(1-hexyloxyethyl)phenyl}-5-decyloxypyrimidine.

출처