반응 #2025290

반응 방정식

sodium borohydride

ethanol

chloroform

2-(4-acetylphenyl)-5-decyloxypyrimidine

→

2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine

수율 99.9%

용매

water

반응 조건

후처리

1. 1
   온도while maintaining the temperature at 30° to 35° C.
2. 2
   추출extracted with 400 ml of ethyl acetate
3. 3
   세척The organic phase was washed sufficiently
4. 4
   건조dried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

실험 절차

To a mixed solvent of 200 ml of ethanol and 100 ml of chloroform were added 35.5 g (0.1 mole) of 2-(4-acetylphenyl)-5-decyloxypyrimidine, and while maintaining the temperature at 30° to 35° C., 2.65 g (0.07 mole) of sodium borohydride were gradually added thereto. After stirring at the same temperature for 4 hours, the reaction mixture was poured into 500 ml of water and extracted with 400 ml of ethyl acetate. The organic phase was washed sufficiently, dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure to obtain 35.6 g (yield: 99.9 %) of 2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine.

출처