반응 #2025285

반응 방정식

hydrochloric acid

acetic acid

4-phenyl-2-butanol

toluene

→

2-acetoxy-4-phenylbutane

수율 98.5%

용매

pyridine

반응 조건

후처리

1. 1
   workup.ADDITIONwere charged
2. 2
   기타to react them for 4 hours
3. 3
   온도while temperature being maintained at 40°-50° C
4. 4
   기타After completion of the reaction
5. 5
   추출extracted
6. 6
   세척an organic layer was washed with 1N hydrochloric acid, water, 5% sodium bicarbonate solution and water in the order
7. 7
   농축The thus-obtained organic layer was concentrated under a reduced pressure

실험 절차

Into a four-necked flask provided with a thermometer and a stirrer, 150 g (1 mol) of 4-phenyl-2-butanol (XXX-35), 500 ml of toluene and 200 ml of pyridine were charged. 122.4 g (1.2 mol) of anhydrous acetic acid and 1 g of 4-dimethylaminopyridine were further added thereto to react them for 4 hours, while temperature being maintained at 40°-50° C. After completion of the reaction, the reaction mixture was poured into 500 ml of 4N hydrochloric acid solution, extracted and fractionated, and then an organic layer was washed with 1N hydrochloric acid, water, 5% sodium bicarbonate solution and water in the order. The thus-obtained organic layer was concentrated under a reduced pressure to obtain 189 g of 2-acetoxy-4-phenylbutane (XXIX-35) with yield of 98.5%.

출처