반응 #2021472

반응 방정식

α-bromo-γ-butyrolactone

methacrylic acid

methyl isobutyl ketone

→

α-methacryloyloxy-γ-butyrolactone

수율 85.0%

용매

triethylamine

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   기타to form a solution
3. 3
   여과After filtration
4. 4
   세척the organic layer was washed with 5% aqueous sodium hydrogen carbonate-solution
5. 5
   세척washed twice with water
6. 6
   농축The organic layer was concentrated

실험 절차

After charging 100 parts of α-bromo-γ-butyrolactone and 104.4 parts of methacrylic acid (2.0 times in mole based on α-bromo-γ-butyrolactone), a three times amount of methyl isobutyl ketone based on α-bromo-γ-butyrolactone was added thereto to form a solution. To this solution was added dropwise 183.6 parts of triethylamine (3.0 times in mole based on α-bromo-γ-butyrolactone). Then, the solution was stirred at room temperature for about 10 hours. After filtration, the organic layer was washed with 5% aqueous sodium hydrogen carbonate-solution and then washed twice with water. The organic layer was concentrated to give α-methacryloyloxy-γ-butyrolactone represented by the following formula in 85% yield:

출처