반응 #2021467

반응 방정식

HCl

4-fluorobenzaldehyde

malonic acid

piperidine

→

4-fluorocinnamic acid

용매

pyridine

반응 조건

후처리

1. 1
   온도cooled
2. 2
   농축a 10% concentration
3. 3
   여과The precipitate is filtered
4. 4
   기타crystallized with ethanol

실험 절차

A mixture of 0.1 mol 4-fluorobenzaldehyde, 0.15 mol malonic acid, and 0.1 ml piperidine in 30 ml pyridine is boiled for 10 hours, cooled, and treated with 150 ml HCl having a 10% concentration. The precipitate is filtered and crystallized with ethanol. The yield of 4-fluorocinnamic acid is 68% and the melting point is 211° C.

출처