반응 #2019044

반응 방정식

tert-Butyl 3-(3-chloro-4-fluorophenyl)-3-hydroxypyrrolidin-1-carboxylate

trifluoroacetic acid

→

3-(3-CHLORO-4-FLUOROPHENYL)PYRROLIDIN-3-OL

용매

dichloromethane

반응 조건

후처리

1. 1
   기타Preparation
2. 2
   기타according to Preparation 2

실험 절차

Preparation according to Preparation 2: tert-Butyl 3-(3-chloro-4-fluorophenyl)-3-hydroxypyrrolidin-1-carboxylate (0.87 g, 2.77 mmol), dichloromethane (3 mL) and trifluoroacetic acid (3 mL). Stirred for 5 h. Yield: 0.31 g. MS m/z (rel. intensity, 70 eV) 215 (M+, 72), 157 (bp), 133 (53), 130 (62), 129 (98).

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