반응 #2019043

반응 방정식

4-bromo-2-chloro-1-fluorobenzene

1-N-boc-3-pyrrolidinone

magnesium

→

TERT-BUTYL 3-(3-CHLORO-4-FLUOROPHENYL)-3-HYDROXYPYRROLIDIN-1-CARBOXYLATE

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타Preparation
2. 2
   기타according to Preparation 5

실험 절차

Preparation according to Preparation 5: 4-bromo-2-chloro-1-fluorobenzene (4.0 g, 19.1 mmol), dry tetrahydrofuran (50 mL), magnesium turnings (0.5 g, 21.0 mmol) and 1-N-boc-3-pyrrolidinone (3.89 g, 21.0 mmol). Yield: 1.65 g. MS m/z (rel. intensity, 70 eV) 315 (M+, 1), 259 (50), 214 (63), 157 (44), 57 (bp).

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