반응 #2016328

ord-73df38ac26084202ab251ef88dc857df

반응 방정식

COc1cc(OC)c2c(COc3cccc4[nH]c(C(=O)O)cc34)coc2c1
4-(4,6-dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid
C[C@H]1CN([C@@H](C)CN2CCC(N)CC2)CC[C@@H]1O.Cl.Cl.Cl
amine
C[C@H]1CN([C@@H](C)CN2CCC(N)CC2)CC[C@@H]1O.Cl.Cl.Cl
(3S,4S)-1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-3-methyl-piperidin-4-ol tri-hydrochloride
→
COc1cc(OC)c2c(COc3cccc4[nH]c(C(=O)NC5CCN(C[C@H](C)N6CC[C@H](O)[C@@H](C)C6)CC5)cc34)coc2c1
4-(4,6-Dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(S)-2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

반응물

COc1cc(OC)c2c(COc3cccc4[nH]c(C(=O)O)cc34)coc2c1
4-(4,6-dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid
C[C@H]1CN([C@@H](C)CN2CCC(N)CC2)CC[C@@H]1O.Cl.Cl.Cl
amine
C[C@H]1CN([C@@H](C)CN2CCC(N)CC2)CC[C@@H]1O.Cl.Cl.Cl
(3S,4S)-1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-3-methyl-piperidin-4-ol tri-hydrochloride

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

This compound is synthesized analogously to example 1 from 4-(4,6-dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid, 126 (see example 99) and amine 56.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08183366B2uspto-grants-2012_05