반응 #2016284

ord-1e3e3490a3904876bf05a70cc0d94af5

반응 방정식

O=C(O)c1cc2c(OCc3coc4cc(F)ccc34)cccc2[nH]1
4-(6-fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid
C[C@H]1CN([C@@H](C)CN2CCC(N)CC2)CC[C@@H]1O.Cl.Cl.Cl
amine
C[C@H]1CN([C@@H](C)CN2CCC(N)CC2)CC[C@@H]1O.Cl.Cl.Cl
(3S,4S)-1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-3-methyl-piperidin-4-ol tri-hydrochloride
→
C[C@H]1CN([C@@H](C)CN2CCC(NC(=O)c3cc4c(OCc5coc6cc(F)ccc56)cccc4[nH]3)CC2)CC[C@@H]1O
4-(6-Fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(S)-2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

반응물

O=C(O)c1cc2c(OCc3coc4cc(F)ccc34)cccc2[nH]1
4-(6-fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid
C[C@H]1CN([C@@H](C)CN2CCC(N)CC2)CC[C@@H]1O.Cl.Cl.Cl
amine
C[C@H]1CN([C@@H](C)CN2CCC(N)CC2)CC[C@@H]1O.Cl.Cl.Cl
(3S,4S)-1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-3-methyl-piperidin-4-ol tri-hydrochloride

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

This compound is synthesized analogously to example 1 from 4-(6-fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid, 106 (see example 55) and amine 56.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08183366B2uspto-grants-2012_05