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rac-N2-[4-(2-methoxy-ethoxy)-2,3-dihydro-benzofuran-3-yl]-quinoline-2,6-diamine

rac-N2-[4-(2-Methoxy-ethoxy)-2,3-dihydro-benzofuran-3-yl]-quinoline-2,6-diamine

(4-methyl-piperazin-1-yl)-acetic acid

→

title compound

rac-N-{2-[4-(2-Methoxy-ethoxy)-2,3-dihydro-benzofuran-3-ylamino]-quinolin-6-yl}-2-(4-methyl-piperazin-1-yl)-acetamide

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실험 절차

The title compound was prepared from rac-N2-[4-(2-methoxy-ethoxy)-2,3-dihydro-benzofuran-3-yl]-quinoline-2,6-diamine (Example 174) (200 mg, 0.4 mmol) and commercially available (4-methyl-piperazin-1-yl)-acetic acid (68 mg, 0.6 mmol) in accordance with the general method 14 described in example 119 and was obtained as an off-white solid (160 mg, 76%); MS: m/e=492.3 (M+H+).

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