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rac-N2-[4-(2-methoxy-ethoxy)-2,3-dihydro-benzofuran-3-yl]-quinoline-2,6-diamine

rac-N2-[4-(2-Methoxy-ethoxy)-2,3-dihydro-benzofuran-3-yl]-quinoline-2,6-diamine

4-nitrophenyl chloroformate

1-isopropyl-piperidin-4-ylamine dihydrochloride

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title compound

rac-1-(1-Isopropyl-piperidin-4-yl)-3-{2-[4-(2-methoxy-ethoxy)-2,3-dihydro-benzofuran-3-ylamino]-quinolin-6-yl}-urea

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실험 절차

The title compound was prepared from rac-N2-[4-(2-methoxy-ethoxy)-2,3-dihydro-benzofuran-3-yl]-quinoline-2,6-diamine (Example 174) (200 mg, 0.57 mmol), 4-nitrophenyl chloroformate (115 mg, 0.57 mmol) and 1-isopropyl-piperidin-4-ylamine dihydrochloride (CAS no: 534596-29-7) (122 mg, 0.57 mmol) in accordance with the general method 4 described in example 170 step C and was obtained as an off-white solid (210 mg, 71%); MS: m/e=520.5 (M+H+).

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