반응 #2010710

반응 방정식

2-{2-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-ethyl}-4-methyl-thiazole-5-carboxylic acid

thiomorpholine

→

title compound

수율 37.0%

(2-{2-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-ethyl}-4-methyl-thiazol-5-yl)-thiomorpholin-4-yl-methanone

수율 37.0%

반응 조건

실험 절차

As described for example 31b, 2-{2-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-ethyl}-4-methyl-thiazole-5-carboxylic acid (69 mg, 0.20 mmol) was converted, using thiomorpholine instead of 4-aminotetrahydropyran, to the title compound (32 mg, 37%) which was obtained as a colourless gum after purification by chromatography (silica, heptane:ethyl acetate 1:0 to 0:1 then dichloromethane:methanol 1:0 to 95:5). MS: m/e=433.2 [M+H]+.

출처