반응 #2010697

반응 방정식

2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid

1,1-dioxidotetrahydrothien-3-ylamine

→

title compound

수율 37.0%

2-[2-(5-Methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (1,1-dioxo-tetrahydrothiophen-3-yl)-amide

수율 37.0%

반응 조건

실험 절차

As described for example 22b, 2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (73 mg, 0.23 mmol) was converted, using 1,1-dioxidotetrahydrothien-3-ylamine instead of isopropylamine, to the title compound (37 mg, 37%) which was obtained as a brown solid MS: m/e=433.3 [M+H]+.

출처