반응 #2010695

반응 방정식

2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid

4-aminotetrahydropyran

→

title compound

수율 46.0%

2-[2-(5-Methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (tetra-hydro-pyran-4-yl)-amide

수율 46.0%

반응 조건

실험 절차

As described for example 22b, 2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (77 mg, 0.24 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (45 mg, 46%) which was obtained as a white solid MS: m/e=399.1 [M+H]+.

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