반응 #2006480

반응 방정식

compound 10a

4-(4,4-Dimethyl-5-imino-2-oxo-1-imidazolidinyl)-2-trifluoromethyl-benzonitrile

bicarbonate

→

desired compound 11a

수율 95.0%

4-(4,4-Dimethyl-2,5-dioxo-1-imidazolidinyl)-2-trifluoromethyl-benzonitrile

수율 95.0%

용매

HCl

반응 조건

후처리

1. 1
   온도was refluxed for 35 min
2. 2
   추출extracted
3. 3
   세척The organic layer was washed with brine
4. 4
   건조finally dried over magnesium sulphate

실험 절차

A suspension of the compound 10a in 6N HCl (25 mL) was refluxed for 35 min. The cooled solution was poured in a 10% bicarbonate solution, extracted using ethyl acetate (3×25 mL). The organic layer was washed with brine, and finally dried over magnesium sulphate to give of desired compound 11a (950 mg, 95%) which was used as such in the next step. 1H NMR (300 MHz, Acetone-d6) δ: 1.54 (s, 6H), 7.81 (broad s, 1H), 8.17 (m, 2H), 8.26 (s, 1H).

출처