반응 #2006430

반응 방정식

2-(6-methyl-2-pyridyl)-1-(6-(phthalimido)hexyl)imidazole

hydrazine hydrate

→

crude product

1-(6-Aminohexyl)-2-(6-methyl-2-pyridyl)imidazole

용매

EtOH

반응 조건

후처리

1. 1
   온도The solution was cooled to room temperature
2. 2
   여과suction filtered
3. 3
   기타to remove the precipitate
4. 4
   기타The filtrate was evaporated

실험 절차

To a solution of 2-(6-methyl-2-pyridyl)-1-(6-(phthalimido)hexyl)imidazole (4.2 g) in 50 mL EtOH was added 1.5 mL hydrazine hydrate. The resulting solution was stirred at 80° C. overnight. The solution was cooled to room temperature and suction filtered to remove the precipitate. The filtrate was evaporated to give the crude product, which was purified by a silica gel column using 5% conc. NH3H2O/CH3CN as the eluent. Yield: about 2.5 g.

출처