반응 #2006423

반응 방정식

4-vinyl-benzoic acid

benzenethiol

VAZO

→

white solid

수율 85.0%

4-(2-Thiophenyl)-ethyl Benzoic Acid

수율 85.0%

용매

benzene

반응 조건

후처리

1. 1
   기타According to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask
2. 2
   온도at reflux
3. 3
   기타the solvent was evaporated under vacuo
4. 4
   기타The solid was purified by trituration

실험 절차

According to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask containing 4-vinyl-benzoic acid (1.0 g, 6.75 mmoles) in 10 mL of benzene (0.7 M) was added benzenethiol (797 μL, 7.76 mmoles) followed by VAZO™ (Aldrich Chemical Company, 495 mg, 2.02 mmoles). The mixture was stirred for 12 hours at reflux. The resulting solution was cooled at room temperature and the solvent was evaporated under vacuo. The solid was purified by trituration using hexane and dichloromethane to afford 1.94 g (85%) of white solid.

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