반응 #2006419

반응 방정식

HCl

methyl ester

Methyl-4-(3-oxo-3-phenylpropyl)-benzoate

LiOH

→

title compound

4-(3-oxo-3-Phenylpropyl)-benzoic Acid

용매

water THF

반응 조건

후처리

1. 1
   추출the solution was extracted with EtOAc
2. 2
   건조the organic layer was dried over anhydrous MgSO4
3. 3
   여과Filtration and evaporation of the solvent under vacuum
4. 4
   기타followed by purification by column chromatography

실험 절차

To a solution of methyl ester 47 (195 mg, 0.73 mmol) in water/THF (1:1, 0.07M) was added LiOH (46 mg, 1.1 mmol). The resulting solution was stirred overnight at room temperature or until no starting material was detected by TLC. HCl 1N was added and the solution was extracted with EtOAc and the organic layer was dried over anhydrous MgSO4. Filtration and evaporation of the solvent under vacuum followed by purification by column chromatography using 10% MeOH/CH2Cl2, gave the title compound.

출처