반응 #2006413

반응 방정식

NaHCO3

Na2CO3

4-(4-aminophenyl)-butyric acid

HCl

→

40

수율 91.0%

Methyl-4-(4-aminophenyl)-butanoate

수율 91.0%

용매

MeOH

반응 조건

후처리

1. 1
   기타The solvent was evaporated under reduced pressure
2. 2
   추출the aqueous phase was extracted several times with CH2Cl2
3. 3
   기타The crude material was purified by flash chromatography

실험 절차

To a solution of 4-(4-aminophenyl)-butyric acid (5 g, 27.90 mmol) in MeOH (100 mL) at room temperature was added HCl conc. (37% 15 mL). The resulting mixture was stirred overnight at 50° C. then treated with a saturated aqueous solution NaHCO3 and Na2CO3 solid until pH 9. The solvent was evaporated under reduced pressure then the aqueous phase was extracted several times with CH2Cl2. The crude material was purified by flash chromatography using CH2Cl2/MeOH as solvent mixture yielding 40 (4.93 g, 91%) as orange solid.

출처