반응 #2004684
ord-67fdef132c814f3ba814d75be9d4cc93
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The solvent was removed in vacuo
실험 절차
To a solution of 3-(tert-butyldimethylsilyloxy)dihydrofuran-2(3H)-one (11 g, 49 mmol) in methanol was added 7 N ammonia in methanol (20 mL, 140 mmol). The reaction was stirred in a sealed tube for 2 days. The solvent was removed in vacuo to yield (S)-2-(tert-butyldimethylsilyloxy)-4-hydroxybutanamide (4.85 g, 20.8 mmol) as a white solid. [M+H] calc'd for C10H23NO3Si, 234; found, 234.