반응 #2002885

반응 방정식

1

2-Fluoro-3-(4-methyl-piperazin-1-yl)-6-nitro-phenylamine

hydroxylamine HCl

pyridine

→

2

3-Fluoro-4-(4-methyl-piperazin-1-yl)-benzene-1,2-diamine

용매

ethanol

반응 조건

후처리

1. 1
   기타The resulting reaction mixture
2. 2
   농축The crude product was concentrated
3. 3
   기타absorbed onto silica gel
4. 4
   기타purified by flash chromatography (97:3 CH2Cl2/MeOH

실험 절차

A 50 mL round bottom flask was charged with 1 (680 mg, 2.5 mmol), hydroxylamine HCl (191 mg, 2.75 mmol), pyridine (0.25 mL, 3.0 mmol) and ethanol (10 mL). The resulting reaction mixture was stirred at rt overnight. The crude product was concentrated, absorbed onto silica gel, and purified by flash chromatography (97:3 CH2Cl2/MeOH to give 2 as an orange solid. LCMS m/z 289.2 (MH+), tR=2.06 min.

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