반응 #2002083

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Compound 1A

Cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodo-phenylamino)-benzooxazol-7-yl]-amide

8-cyclopropanesulfonyl-4,5-difluoro-6-(2-fluoro-4-iodo-phenyl)-2-methyl-6,8-dihydro-imidazo[4′,5′:3,4]benzo[1,2-d]oxazol-7-one

potassium

→

Compound 1E

Cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodo-phenylamino)-2-methyl-benzooxazol-7-yl]amide

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실험 절차

Compound 1E was prepared from 8-cyclopropanesulfonyl-4,5-difluoro-6-(2-fluoro-4-iodo-phenyl)-2-methyl-6,8-dihydro-imidazo[4′,5′:3,4]benzo[1,2-d]oxazol-7-one (I-22a: 55 mg, 0.12 mmol) and potassium trimethylsilonolate (30 mg, 0.18 mmol) using procedures analogous to those described above for Compound 1A to afford 3 mg of the product (5.66% yield). H1NMR (CDCl3, 300 MHz): δ 7.40 (d, 1H), 7.30-7.22 (m, 1H), 6.59 (s, 1H), 6.49 (s, 1H), 6.40-6.30 (m, 1H), 2.70 (s, 3H), 2.66-2.58 (m, 1H), 1.22-1.14 (m, 2H), 1.04-0.94 (m, 2H). LCMS: 82.6%, m/z=523.6 (M+1). HPLC: 99.35%.

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