반응 #2000563

반응 방정식

5′-(5-Cyano-1-methyl-1H-pyrrol-2-yl)spiro[cyclohexane-1,3′-[3H]indol]-2′-ylidenecyanamide

diethylamine

→

diethylamine

수율 184.1%

5′-(5-Cyano-1-Methyl-1H-Pyrrol-2-Yl)Spiro[Cyclohexane-1,3′-[3H]Indol]-2′-Ylidenecyanamide Diethylamine Salt

수율 184.1%

용매

THF

반응 조건

후처리

1. 1
   온도refluxed until a solution
2. 2
   기타was obtained
3. 3
   기타a white precipitate was formed
4. 4
   여과The solution was filtered
5. 5
   세척the precipitate washed with THF
6. 6
   기타dried

실험 절차

5′-(5-Cyano-1-methyl-1H-pyrrol-2-yl)spiro[cyclohexane-1,3′-[3H]indol]-2′-ylidenecyanamide (16 g) in THF (100 mL) was treated with diethylamine (37 g) and refluxed until a solution was obtained. Upon cooling to ambient temperature, a white precipitate was formed. The solution was filtered, the precipitate washed with THF and dried to give 18.0 g (90% yield) of the diethylamine salt/complex. 1H NMR (DMSO-d6, ppm): 7.58, 7.21, 7.05, 7.00, 6.5-6 (br), 6.27, 3.71, 2.80 (q), 1.9-1.7, 1.5-1.4, and 1.10 (t).

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