반응 #2000322

반응 방정식

2,2,2-trifluoro-N-(4-hydroxy-cyclohexyl)-N-methyl-acetamide

2,2,2-Trifluoro-N-(4-hydroxy-cyclohexyl)-N-methyl-acetamide

→

4-methylamino-cyclohexanol

수율 126.4%

trans-4-Methylamino-cyclohexanol

수율 126.4%

용매

HCl

water

반응 조건

후처리

1. 1
   온도heated in a microwave at 150° until conversion

실험 절차

2 g of 2,2,2-trifluoro-N-(4-hydroxy-cyclohexyl)-N-methyl-acetamide (149) were suspended in 10 mL of 1 N HCl and heated in a microwave at 150° until conversion was complete. The resulting solution was lyophilized and the residue was taken up in water and lyophilized again, twice to yield 1.45 g of 4-methylamino-cyclohexanol (150). Rt=0.13 min (Method C). Detected mass: 130.3 (M+H+).

출처