반응 #1999752

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methyl 2-(tert-butoxy)-2-(6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

2-(bromomethyl)-1-chloro-3,4-difluorobenzene

→

title compound

2-(tert-butoxy)-2-(1-(6-chloro-2,3-difluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

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실험 절차

The title compound was prepared from methyl 2-(tert-butoxy)-2-(6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 2-(bromomethyl)-1-chloro-3,4-difluorobenzene in a manner similar to that described in Example 25 as a yellow solid. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm=7.68-7.62 (m, 1 H), 7.44-7.39 (m, 1 H), 7.35 (d, J=7.8 Hz, 2 H), 7.31-7.25 (m, 1 H), 7.12 (d, J=3.5 Hz, 1 H), 6.96 (dd, J=8.4, 10.5 Hz, 1 H), 6.29 (d, J=3.5 Hz, 1 H), 5.64-5.52 (m, 3 H), 2.75 (s, 3 H), 2.48 (s, 3 H), 0.96 (s, 9 H); LCMS (m/z) ES+=513 (M+1).

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