반응 #1994291

반응 방정식

6-Amino-2,5-dichloropyrimidine-4-carboxylic acid methyl ester

cesium fluoride

4-chloro-2-fluorophenylboronic acid

→

title compound

수율 40.8%

6-Amino-5-chloro-2-(4-chloro-2-fluorophenyl)pyrimidine-4-carboxylic acid methyl ester

수율 40.8%

용매

water

1,2-dimethoxyethane

ethyl acetate

반응 조건

후처리

1. 1
   기타The cooled reaction mixture
2. 2
   세척washed with water
3. 3
   기타dried
4. 4
   농축concentrated
5. 5
   기타The product was purified by column chromatography (methylene chloride/ethyl acetate gradient)
6. 6
   기타then purified again by column chromatography (ethyl acetate/hexane gradient)

실험 절차

6-Amino-2,5-dichloropyrimidine-4-carboxylic acid methyl ester (1.11 g, 5 mmol, see WO 2007/082076 A1 for preparation), 4-chloro-2-fluorophenylboronic acid (1.13 g, 6.5 mmol), bis(triphenylphosphine)-palladium(II) dichloride (350 mg, 0.5 mmol), and cesium fluoride (1.52 g, 10 mmol) were combined in 10 mL of 1,2-dimethoxyethane (DME) and 10 mL of water. The reaction mixture was heated in a CEM microwave at 100° C. for 15 minutes. The cooled reaction mixture was diluted with ethyl acetate, washed with water, dried and concentrated. The product was purified by column chromatography (methylene chloride/ethyl acetate gradient) then purified again by column chromatography (ethyl acetate/hexane gradient) to yield the title compound (574 mg, 40.8% yield): mp 194-196° C.; 1H NMR (CDCl3): δ 7.96 (m, 1H), 7.2 (m, 2H), 5.64 (br s, 2H), 4.01 (s, 3H).

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