반응 #1994258

반응 방정식

10-(biphenyl-4-yl)-9,10-dihydroacridine

bromosuccinimide

→

10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine

수율 77.7%

용매

chloroform

반응 조건

후처리

1. 1
   세척the resultant solution was washed with distilled water
2. 2
   추출Then, an organic layer was extracted
3. 3
   건조dried with sodium sulfate so as
4. 4
   기타to remove the solvent
5. 5
   기타The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20))

실험 절차

The obtained 10-(biphenyl-4-yl)-9,10-dihydroacridine (15.3 g, 45.9 mmol) was added with chloroform (500 ml), and then with bromosuccinimide (9.8 g, 55.1 mmol). The resultant solution was stirred at room temperature for 2 hours. After the reaction was completed, the resultant solution was washed with distilled water. Then, an organic layer was extracted and dried with sodium sulfate so as to remove the solvent. The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20)) to obtain 10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine compound (white solid, 14.7 g, yield 77%).

출처